Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias
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چکیده
منابع مشابه
Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.
BACKGROUND Laboratory diagnosis of erythropoietic protoporphyria (EPP) requires a marked increase in total erythrocyte protoporphyrin (300-5000 μg/dL erythrocytes, reference interval <80 μg/dL) and a predominance (85%-100%) of metal-free protoporphyrin [normal, mostly zinc protoporphyrin (reference intervals for the zinc protoporphyrin proportion have not been established)]; plasma porphyrins a...
متن کاملEFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS
Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was mea...
متن کاملFree erythrocyte protoporphyrin.
Porphyrins are widely distributed in living cells throughout nature and play essential roles in various metabolic processes such as photosynthesis, transportation of oxygen and cellular respiration. In man the most important of the porphyrins is protoporphyrin 9, type III, which in combination with iron and specific proteins forms such compounds as hemoglobin, myoglobin, cytochrome, peroxidase ...
متن کاملeffect of chronic lead poisoning on erythrocyte protoporphyrin in rats
research has shown that exposure to lead may have adverse effects at different blood lead concentrations. lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. therefore the concentration of protoporphyrin increases in erythrocytes. the concentration of lead was measure...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2015
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2015.245456